Sri Muthukumaran Medical College

SRI MUTHUKUMARAN MEDICAL COLLEGE
HOSPITAL AND RESEARCH INSTITUTE

SRI MUTHUKUMARAN MEDICAL COLLEGE HOSPITAL AND RESEARCH INSTITUTE

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About The Department

The Department of Biochemistry is the heart of the medical institutions and provides feather to the institute by offering tremendous potential in basic as well as applied medical sciences. The Department of Biochemistry at Sri Muthukumaran Medical College Hospital and Research Institute was established in 2010.  Biochemistry, the sole of medicine is an excellent and essential component of curriculum for all categories of health professionals. The Department has a well-equipped student lab, two demonstration halls and a seminar cum library room well equipped with textbooks and reputed journals. The Department has qualified, well experienced and passionate faculty who are committed to inspire the students in academics as well as research. The department trains the students in a clinical oriented manner so that they can apply their knowledge for patient care and to prepare for competitive exams. The faculties achieved many awards and prizes in various conferences and academic forum. Our department faculties are actively involved in various scientific societies at national and international level.

Diagnostics   

Clinical Biochemistry Laboratory

Clinical Biochemistry tests comprises over one third of all hospital laboratory investigations. Clinical biochemistry is the branch of laboratory medicine in which chemical and biochemical methods are applied to the study of disease while in theory this embraces all non-morphological studies, in practice it is usually, though not exclusively, confined to studies on blood and urine because of the relative ease in obtaining such specimens although analysis are made on other body fluids such as pleural, gastric and cerebrospinal fluid.

Equipments

Our clinical Biochemistry Laboratory is equipped with the following instruments providing 24 hours patients care services,Fully automated chemistry analyzer : Thermofisher – Kone Lab-20

  • Fully automated immunoassay system: MiniVidas
  • Semi automated analyzer: Erba Chem 7 and Merilyzer
  • Electrolyte analyzer: Starlyte
  • Arterial Blood Gas analyzer: Radiometer
  • Electrophoresis

List of Investigations

The following list of investigations are performed in our clinical biochemistry lab

Diabetic profile:

  • Fasting blood sugar (FBS)
  • Post-prandial blood sugar (PPBS)
  • Oral glucose clearance test (OGCT)
  • Oral glucose tolerance test (OGTT)
  • Mean blood glucose (MBG)
  • Glycated hemoglobin (HbA1c)

Liver Function Test:

  • Total Bilirubin
  • Direct Bilirubin
  • Aspartate amino transferase (AST)
  • Alanine amino transferase (ALT)
  • Alkaline phosphatase (ALP)
  • Lactate dehydrogenase (LDH)
  • Total Protein
  • Serum Albumin
  • Serum globulin
  • Albumin globulin ratio

Lipid profile:

  • Triglyceride
  • Total Cholesterol
  • HDL-Cholesterol
  • LDL-Cholesterol
  • VLDL-Cholesterol

Renal profile:

  • Urea
  • Creatinine
  • Uric acid

Electrolytes:

  • Sodium
  • Potassium
  • Chloride

Arterial blood Gases:

  • pH
  • pO2
  • pCo2
  • Calculated Bicarbonate

Other enzyme profile:

  • Amylase

Cardiac profile:

  • Troponin – I
  • Lipid Profile

Coagulation profile:

  • Prothrombin time (PT)
  • Activated prothrombin time (APTT)
  • International normalized ratio (INR)

Bone profile:

  • Calcium Phosphorus
  • Alkaline phosphatase (ALP)
  • Vitamin D3

Thyroid profile:

  • TSH
  • fT3
  • fT4

Fertility profile:

  • LH
  • FSH
  • Prolactin

COVID-19 Profile:

  • D-Dimer
  • Ferritin
  • LDH

Urine profile:

  • Microprotein
  • Microalbumin
  • Protein creatinine ratio (PCR)
  • Urine Creatinine

Fluid analysis:

  • CSF (Sugar, Protein & LDH)
  • Pleural fluid (Sugar, Protein & LDH)
  • Peritoneal fluid (Sugar, Protein & LDH)
  • Synovial fluid (Sugar, Protein & LDH)

Services Offered

The biological patient’s samples were collected at different wards and out patients sample collection units by well trained technicians and release of reports within a appropriate turnaround time to enable early diagnosis and treatment.

  • Laboratory services for patients such as Clinical chemistry, Immunoassay, Electrolytes, Arterial blood gas analysis, urine analysis, coagulation profile, fluid analysis and special analytes.
  • Laboratory Internal Quality Control (IQC) is maintained with Bio-Rad quality control samples periodically.
  • External Quality Control program (EQAS) conducted by CMC, Vellore.
  • Biomedical waste
  • Water distillation unit for double distilled water .

Head of the Department

Dr. P. Mohanalakshmi MBBS.,MD

List of Faculties

Dr Nandakumar – Professor
Ms Akila.S -Tutor/Demonstrator 
Dr. Akhileshwaran C -Tutor/Demonstrator  
Dr. Nandha Kumar – Tutor/Demonstrator 
Dr. Sree Vishnu Sakthi S – Tutor/Demonstrator 

Publications

  1. Rahul. G, Nandhakumar. E, Mohanalakshmi.  P, Beneficial effect of polyherbal formulation (PHF) on altered glycoprotein components in high fat diet induced type II diabetic rats. Current trends in multi disciplinary research 2021.
  2. Ganesh, Muthu, Nandhakumar. E, Sundaram. R. Hepatoprotective and anti-inflammatory potential of chebulagic acid on carbon tetrachloride induced hepatic fibrosis by antioxidative activities in rats. Comparative clinical pathology 2021.
  3. Rahul. G, Nandhakumar. E & Renuka. A. Effect of polyherbal drug on oxidative stress and insulin resistance in high-fat diet-induced type 2 diabetic rats. Frontiers in life science 2020, Vol.13, No 1, 310-320.
  4. Xianfu sun, Periyankaruppan. P, Naresh Kumar. R, Harshavardhan. S, Nicolette Naden H, Dunia A. Farraj, Yousif M. Elnahas,      Nandhakumar. E Mariappan R. Natural deep entectic solvent supported targeted solid-liquid polymer carrier for breast cancer therapy, RSC Adv., 2020, 10, 36989-37004.
  5. Rahul G, Nandhakumar E & Renuka A. Effect of polyherbal drug on oxidative stress and insulin resistance in high-fat diet-induced type 2 diabetic rats, frontiers in life science 2020, VOL. 13, NO. 1, 310-320.
  6. Rashmi, Modagan P & Santhi S. FGF-21 as a bone adiposity marker in osteoporosis. Ann Tro Med & Public Health. 2020; 22 (S23): SP2323271. DOI.
  7. Deepti. R & Akila. S Assessment of uric acid status in obese individuals. Ejpmr,2020, 7(11),449-452
  8.  Akila. S & Deepti. R Etiology of cancer: A deadly ocean. Ejpmr, 2020, 7(5),684-690
  9.  Mohanalakshmi. P & Muninathan. N, Gender wise comparison of biochemical variables in normal individuals and chronic kidney disease patients with diabetes mellitus. Medpulse International Journal of Biochemistry November 2019, 12(2): 72-75.
  10.  Mohanalakshmi. P &  Muninathan. N. Uric acid as a biomarker for Pre diabetic & type 2 diabetic patients.  Scholars international journal of biochemistry. 2019.Vol 2, Issue 5,Pg no 141-144.
  11. Radharaja Prabhu. K, Mohanalakshmi. P, Chittambalam. P.C  & Sathish Selvakumar. A. Case control evaluation of serum vitamin D levels in psoriasis. Indian journal of clinical & experimental dermatology. 2019, Vol 5(1). 
  12. Sundaram. R, Nandhakumar. E & Haseena Banu. H. Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Toxicology mechanisms & methods. 14 Aug  2019, 29(9):644-653.
  13. Rahul. G, Nandhakumar. E, Renuka. A, Manamalli. A. Antidiabetic potential of polyherbal drug against high fat diet induced type 2 diabetes mellitus male wister rats. Drug Inventation Today 11 (7)  2019, 1-5.
  14. Vinothini. K, Rajendran. NK, Ramu. A, Nandhakumar. E, Rajan. M. Folate receptor targeted delivery of paclitaxel to breast cancer cells via folic acid conjugated grapheme oxide grafted methyl acrylate nanocarrier. Biomedicine & Pharmacotherapy  2019 , 110 906-917.
  15. Kandasamy. V, NareshKumar. R, Andy. R, Nandhakumar. E, Mariappan Rajan, Folate receptor targeted delivery of paclitaxel to breast cancer cell via folic acid conjugated grapheme oxide grafted methyl acrylate nanocarrier, Biomedicine & Pharmacotherapy, 2019  906-917.
  16. Modagan. P, Santhi Silambanan, Gopinath Menon. P & Arunalatha. P. Serum 25-hydroxy vitamin D levels as an indicator of bone mineral density in osteoporosis. JCDR. 2018: Aug, Vol 12 (8): BC 19- BC 21.
  17. Modagan. P, Santhi Silambanan, Gopinath Menon. P & Arunalatha. P. Comparison of bone mineral density with biochemical parameters and prevalence of osteoporosis in south Indian population. Biomedical and pharmacology journal. 2018; Vol. 11 (4), 2209-2214.
  18. Akila. S, Pullaiah. P, Deepti. R and Ramesh Bharathi. L. Influence of age and gender on renal function by using eGFR in healthy population. European journal of Biomedical and pharmaceutical science. 2018, vol 5, iss 7, 560-563.
  19.  Deepti. R, Akila. S and Ramesh Bharathi. L. Cancer cell and its oncometabolites. Asian Journal of pharmaceutical research. 2018, vol 8,               iss 2, 39 -44.
  20.  Nandhakumar. E, Indumathi. P & Sachdanandam. P. Anticancer Effect of Methanolic Extract of Annona squamosa on Mannary Carcinoma in Rats with Reference To Glycoprotein Components, Lysosomal And Marker Ensymes.Academic Sciences Asian Journal of Pharmaceutical and Clinical Research . 2017. Vol 10(9).
  21. Mohanalakshmi. P & Muthumeenakshi. P. Effects of Swimming Combined Training on Lipid Profiles in male Adolescent Swimmers. Journal of Medical Science and Clinical Research. Vol 3, 2016. Issue 11, Pgs 14071-14075.
  22. Modagan. P,  Renuka. A & Manamalli. A. Prevalence of thyroid dysfunction among adult population of kanchipuram district. European Journal of Biomedical & Pharmaceutical Science. 2016. Vol 3(7)            pg 434-437.
  23. Nandhakumar. E, Purushothama. A, Shanthi. P & Sachdanandam. P. Invtro antioxidant potential of shemamruthaa (a herbal formulation) and its anticancer activity in MCF-7-cell line. RSL Advances. 2015. 5, 23125-23133.
  24. Nandhakumar. E, Purushothama. A, Shanthi. P & Sachdanandam. P. Shemamruthaa, a Herbak Formulation Induces Apoptosis in Breast Cancer cells and inhibit Tumour Progression in Rats. Journal of Evidence Based Complementry & Alternative Medicine (Available Online) 2015.
  25. Nandhakumar. E, Purushothama. A, Shanthi. P & Sachdanandam. P. Antiproliferative and Apoptotic Effect of Shemamruthaa, a Herbal Preparation In 7,12dimethylbenz[a]anthracene unduced Breast Cancer Rats. Journal of Evidence Based Complementry & Alternative Medicine. 2015. 20(4) 259-68
  26. Nandhakumar. E, Suganthi. H, haseena Banu & Yamini. SL. Hepatoprotectin effects of ethanolic effect of whole plant of Andrographis Paniculata against ccl4 induced hepatotoxicity in rats.Com. Clin Pathology.    2015, 24(5) 1245-1251.
  27. Akila. S, Deepti. R, Ramesh. L, Saritha. B & Renuka. A. The impact of increased serum GGT levels and NAFLD on the components of metabolic syndrome. Journal of current trends in clinical medicine and laboratory biochemistry. 2015, vol 2 (4):35-39.
  28. Deepti. R, Nalini. G & Renuka. A. Evaluation of serum magnesium levels in type 2 diabetes mellitus. J Clin Biomed Sci. 2015;5(2):78-82.
  29. Akila. S, Deepti. R, Ramesh. L, Saritha. B & Renuka. A. The impact of increased serum GGT levels and NAFLD on the components of metabolic syndrome. Journal of current trends in clinical medicine and laboratory biochemistry. 2015, vol 2 (4):35-39.
  30. Mohanalakshmi. P, Correlation of Lipoprotein (a) in normal individuals and in chronic kidney patients with Diabetes Mellitus, International Journal of Current Microbiology and Applied Sciences 2014 , 3(3) :1074-1080.
  31. Muninathan. N, Mohanalakshmi. P. A combination of Paclitaxel and Diallyl sulfide on the activities of Mitrochondrial ezymes changes in 7, 12 dimethyl benz(a) anthracene induced skin cancer wistar rats, International Journal of Current Biotechnology 2014, Vol 2(8): 13-17.
  32.  Mohanalakshmi. P. Comparative study of Lipoprotein (a) and lipid profile in Chronic kidney Disease patients on Hemodialysis and without Hemodialysis, Journal of Evolution of medical and dental science, Vol 3, Issue 43, September 2014.
  33. Nandhakumar. E, Purushothama. A, Shanthi. P & Sachdanandam. P. Free radical tuenchie effect of shemamruthaa a siddha drug. In  Dimethylbenza (a) antharane induced experimental breast cancer rats. Comparatie clinical pathology. 2014. 23 (6) 1703-1713.
  34. Nandhakumar. E, Purushothama. A, Shanthi. P & Sachdanandam. P. Shemamruthaa, a herbal formulation modulates xenobiotic and carbohydrate metabolizing enzymes in 7, 12-Dimethylbenz[a]anthracene induced breast cancer in rats. Journal of biochemical Technology. 2014. 5(4), 801-807.
  35. Nandhakumar. E, Purushothama. A & Sachdanandam. P. Protective effect of shemamruthaa on lipids anomalies in 7, 12 Dimethylbenz (A) Anthracene (DMBA) unduced mammary carcinima bearing rats.Medicinal Chemistry Research. 2014.  23(7),  pp 3491-3502.
  36. Nandhakumar. E, Purushothama. A & Sachdanandam. P. Acute and subacute toxicity studies with shemamruthaa a modified indigenous siddha preparation in Sprague-Dawley rats. Food Science and Biotechnology. 2014.  Vol 23, Issue 1, pp 299-306.
  37. Modagan. P, Renuka. A & Manamalli. A, Increased infertility rate with association of hypothyroidism and hyperprolactinaemia in irregularly menstruating women, International Journal of Biochemistry. April – Aug Photon 196,  2014,  434 – 438.
  38. Deepti. R, Nalini. G & Renuka. A. Relationship between hypomagnesemia and dyslipidemia in type 2 diabetes mellitus. Asian J Pharmaceut Res Health care. 2014;6(3):32-36.
  39. Deepti. R, Nalini. G & Renuka. A. Magnesium plays a salient role in the cells. J. Clin Biomed Sci. 2014; 4(4): 341-345.
  40. Nandhakumar. E. Indumathi. P, in vitro Antioxidant Activities of Methanol and Aqueous Extract of Annona squamosa (L.) Fruit Pulp. Journal of Acupuncture Meridian Studies 2013; 6(3):142 – 148
  41. Purushothaman. A, Nandhakumar. E, Sachdanandam. P. Phytochemical analysis and anticancer capacity of Shema mruthaa, a Herbal formulation against DMB A- induced mammary carcinoma in rats. Asian Pacific Journal of Tropical Medicine. 2013; 6(12): 925-33 Science Direct Top 25 (Ranked 7th on the Top 25 Hottest Articles / Most downloaded.)
  42. Modagan. P, Meera sivasekar, Sundravadivelu, Uric Acid as a Mediator of Endothelial Dysfunction in Hypertension, International journal of Research Pharmaceutical and Biomedical sciences 2013, Vol. 4 (1) Jan- March    (ISSN : 2229 -3701).
  43. Modagan. P,  Swetha Narayanan, A correlative study of biochemical parameters in polycystic ovarian syndrome, International Journal of Biological and Medical Research 2013,  vol. 4(2): 3148 – 3154.
  44. Akila. S, Prevalence of Metabolic Syndrome and its components in women with subclinical hypothyroidism, Asian journal of Pharmaceutical research, 2013, vol 6(4) : 82-84 September.
  45. Purushothaman. A, Nandhakumar. E, Sachdanandam. P. Modulation of lipid peroxidation  and antioxidant status upon administration of ‘Shema mruthaa’ in 7, 12-dimethyibenz(a) anthrancene induced mammary carcinoma bearing rats. Asian Pacific Journals of Tropical Biomedicine (2012) 1-7.
  46. Purushothaman. A, Nandhakumar. E, Sachdanandam. P. Anticancer effect of Shema mruthaa (a phytochemical formulation) on 7, 12-dimethylbenz(a) anthrancene induced mammary carcinoma in rats. Academic Science Asian Journal of Pharmaceutical and Clinical Research  2012 , Vol 5, Suppl 1.